Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
Man Tong, Tin Lok Wong, Hongzhi Zhao, Yuanyuan Zheng, Yunong Xie, Cheuk-Hin Li, Lei Zhou, Noélia Che, Jing‐Ping Yun, Kwan Man, Terence K. Lee, Zongwei Cai, Stephanie Ma
Abstract
(Cell Reports 36, 109617-1–109617-14.e1–e5; August 24, 2021) In the originally published version of this article, the lead contact was assigned unwittingly and wrongly to Dr. Man Tong. The correct lead contact for this article is Dr. Stephanie Ma. The authors regret this error. Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancerTong et al.Cell ReportsAugust 24, 2021In BriefTong et al. report that deranged tyrosine catabolism can predict poor prognosis in human liver cancer. Loss of tyrosine catabolic enzyme HPD promotes glutamine dependency and supports hepatic tumorigenesis, which could be exploited as a metabolic vulnerability for liver cancer treatment. Full-Text PDF Open Access