Litcius/Paper detail

Reinforcement Learning Approach to Feedback Stabilization Problem of Probabilistic Boolean Control Networks

Antonio Acernese, Amol Yerudkar, Luigi Glielmo, Carmen Del Vecchio

2020IEEE Control Systems Letters70 citationsDOI

Abstract

In this letter, we study the control of probabilistic Boolean control networks (PBCNs) by leveraging a model-free reinforcement learning (RL) technique. In particular, we propose a Q-learning (QL) based approach to address the feedback stabilization problem of PBCNs, and we design optimal state feedback controllers such that the PBCN is stabilized at a given equilibrium point. The optimal controllers are designed for both finite-time stability and asymptotic stability of PBCNs. In order to verify the convergence of the proposed QL algorithm, the obtained optimal policy is compared with the optimal solutions of model-based techniques, namely value iteration (VI) and semi-tensor product (STP) methods. Finally, some PBCN models of gene regulatory networks (GRNs) are considered to verify the obtained results.

Topics & Concepts

Reinforcement learningProbabilistic logicConvergence (economics)Computer scienceStability (learning theory)Mathematical optimizationState (computer science)Optimal controlControl (management)Control theory (sociology)MathematicsAlgorithmArtificial intelligenceMachine learningEconomic growthEconomicsGene Regulatory Network AnalysisMitochondrial Function and Pathology