Identification of GSPT1 as prognostic biomarker and promoter of malignant colon cancer cell phenotypes via the GSK-3β/CyclinD1 pathway
Xuan Long, Lijun Zhao, Guoqiang Li, Ziwei Wang, Zhigang Deng
Abstract
in HCT116 colon cancer cells. Taken together, our findings suggest that the GSPT1/GSK pathway exerts tumor-promoting actions in colon cancer oncogenesis and progression. The GSPT1/GSK pathway may thus be an effective target for controlling colon cancer.
Topics & Concepts
PhenotypeBiomarkerIdentification (biology)Colorectal cancerCancer researchBiologyCancerComputational biologyMedicineGeneticsGeneBotanyEpigenetics and DNA MethylationCancer-related gene regulationRNA modifications and cancer