Diaryl azo derivatives as anti-diabetic and antimicrobial agents: synthesis, <i>in vitro</i>, kinetic and docking studies
Tehreem Tahir, Mirza Imran Shahzad, Rukhsana Tabassum, Muhammad Rafiq, Muhammad Ashfaq, Mubashir Hassan, Katarzyna Kotwica-Mojzych, Mariusz Mojzych
Abstract
) was performed which showed that the compound is a non-competitive inhibitor and effectively inhibits the target enzyme by binding to its binuclear active site reversibly.
Topics & Concepts
ChemistryAcarboseAntimicrobialDocking (animal)StereochemistryEnzymeNon-competitive inhibitionIC50GramActive siteDiazoGram-negative bacteriaIn vitroCombinatorial chemistryBiochemistryBacteriaOrganic chemistryEscherichia coliBiologyMedicineNursingGeneticsGeneComputational Drug Discovery MethodsSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds