Pten haploinsufficiency causes desynchronized growth of brain areas involved in sensory processing
Amy E. Clipperton‐Allen, Hannah Swick, Valentina Botero, Massimiliano Aceti, Jacob Ellegood, Jason P. Lerch, Damon T. Page
Abstract
mice onto relevant brain regions suggested abnormal behavior is likely when associated with relatively enlarged brain regions, while unchanged or relatively decreased brain regions have little predictive value.
Topics & Concepts
PTENHaploinsufficiencyMacrocephalyNeurosciencePhenotypeAutismSensory systemSensory gatingSensory processingBiologyPsychologyGeneticsGatingPI3K/AKT/mTOR pathwayDevelopmental psychologyGeneApoptosisRNA regulation and diseaseRetinal Development and DisordersRNA and protein synthesis mechanisms