Sunitinib-based Proteolysis Targeting Chimeras (PROTACs) reduced the protein levels of FLT-3 and c-KIT in leukemia cell lines
Jiadai Zhai, Chuang Li, Bingxia Sun, Sinan Wang, Yuting Cui, Qingzhi Gao, Feng Sang
Topics & Concepts
ProteasomeProteolysisChemistryK562 cellsTyrosine kinaseSunitinibProtein degradationUbiquitinLeukemiaCancer researchIn vitroPharmacologyBiochemistryCancerBiologySignal transductionImmunologyEnzymeGeneticsGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments