A two-pronged strategy to alleviate tumor hypoxia and potentiate photodynamic therapy by mild hyperthermia
Zhijie Zhang, Zibing Wang, Yuxuan Xiong, Chong Wang, Qingyuan Deng, Tian Yang, Qingqing Xu, Zhengtao Yong, Xiangliang Yang, Zifu Li
Abstract
to tumors. Thereafter, under 606 nm laser irradiation, Ce6-mediated PDT generated excessive reactive oxygen species (ROS) that induced tumor cell apoptosis and achieved a high tumor inhibition rate of 92.2% in 4T1 breast tumors. Our work indicated that the alleviation of tumor hypoxia from both internal and external pathways significantly enhanced Ce6-mediated PDT against breast cancers.
Topics & Concepts
Photodynamic therapyCatalasePhotothermal therapyChemistryHyperthermiaCancer researchPhotosensitizerHypoxia (environmental)Reactive oxygen speciesTumor hypoxiaTumor microenvironmentExtracellular matrixBiophysicsRadiation therapyOxidative stressBiochemistryOxygenMedicineNanotechnologyTumor cellsMaterials scienceInternal medicineBiologyPhotochemistryOrganic chemistryNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisExtracellular vesicles in disease