Wash-free 3D imaging and detection of glioma with a novel neuropotential targeted AIE probe
Junyong Wu, Anyao Bi, Fan Zheng, Shuai Huang, Yongjiang Li, Jipeng Ding, Da-Xiong Xiang, Wenbin Zeng
Abstract
We herein developed a novel tetraarylimidazole-based AIE probe TPIG-NP to selectively image and quantitatively detect glioma. Due to the distinct negatively charged glioma cells, TPIG-NP with an opposite charge could achieve wash-free imaging of glioma cells and 3D multicellular spheroids.
Topics & Concepts
NanoprobeSchematicGliomaNanotechnologyChemistryMaterials scienceCancer researchMedicineNanoparticleEngineeringElectronic engineeringNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesLuminescence and Fluorescent Materials