Water-soluble thienoviologen derivatives for imaging bacteria and antimicrobial photodynamic therapy
Mengying Guo, Kun Zhou, Rui Ding, Xiaodan Zhao, Yueyan Zhang, Zixi Zhang, Gang He
Abstract
A series of thienoviologen derivatives ( nTPy-R s) were synthesized as novel bacteria imaging and PDT agents. The antibacterial PDT effects of nTPy-R s were significantly enhanced and achieved the minimum inhibitory concentration (MIC) to ng mL −1 level.
Topics & Concepts
ThiophenePhotodynamic therapyCationic polymerizationAntimicrobialPhotosensitizerAntibacterial activityMinimum inhibitory concentrationCytotoxicityAlkylReactive oxygen speciesChemistryCombinatorial chemistryBacteriaIn vivoSolubilityRadicalNuclear chemistryPhotochemistryOrganic chemistryBiochemistryIn vitroBiologyGeneticsBiotechnologyNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Photocatalysis Techniques