N‐Heterocyclic Carbene Catalyzed Photooxidation: Intramolecular Cross Dehydrogenative Coupling of Tetrahydroisoquinoline‐Tethered Aldehydes
Zhong‐Hua Gao, Zihao Xia, Lei Dai, Song Ye
Abstract
Abstract An N‐heterocyclic carbene catalyzed photooxidation reaction via intramolecular cross dehydrogenative coupling of tetrahydroisoquinoline‐tethered aldehydes was developed, giving the corresponding oxidative cyclization products in moderate to good yields. This reaction features mild conditions with oxygen as the terminal oxidant in the absence of photocatalyst. magnified image
Topics & Concepts
ChemistryIntramolecular forceCarbeneTetrahydroisoquinolineCatalysisPhotochemistryStereochemistryOrganic chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions