The role of lipid oxidation pathway in reactive oxygen species-mediated cargo release from liposomes
Olga Lem, Roosa Kekki, Artturi Koivuniemi, Alexander Efimov, Timo Laaksonen, Nikita A. Durandin
Abstract
presence of hydroperoxides is enough to make the bilayer more permeable just for water and small molecules. This is an important finding that shed a light on the release mechanism of different cargo molecules from ROS-sensitive drug delivery systems.
Topics & Concepts
Reactive oxygen speciesLiposomeChemistryLipid oxidationCell biologyBiophysicsBiochemistryBiologyAntioxidantMolecular Sensors and Ion DetectionNanoparticle-Based Drug DeliveryLipid Membrane Structure and Behavior