Multifunctional platinum(<scp>iv</scp>) complex bearing HDAC inhibitor and biotin moiety exhibits prominent cytotoxicity and tumor-targeting ability
Weinan Han, Weiyu He, Yutong Song, Jian Zhao, Zhiheng Song, Yi Shan, Wuyang Hua, Yanyan Sun
Abstract
A multifunctional platinum( iv ) compound conjugated with phenylbutyric acid and biotin was prepared. Biological evaluations demonstrated the prominent antitumor activity and tumor targeting ability as well as the mitochondrial apoptotic pathway.
Topics & Concepts
MoietyCytotoxicityBiotinChemistryPlatinumBearing (navigation)StereochemistryCombinatorial chemistryBiochemistryIn vitroCatalysisComputer scienceArtificial intelligencePeptidase Inhibition and AnalysisInorganic Chemistry and MaterialsSemiconductor materials and devices