A first-in-human phase I/Ib dose-escalation clinical trial of the autophagy inducer ABTL0812 in patients with advanced solid tumours
Laura Vidal, Iván Victoria, Lydia Gaba, Marta Gil-Martín, Merçè Brunet, Helena Colom, Marc Cortal, Mariana Gómez-Ferrería, Marc Yeste‐Velasco, Antonio Valdivia Pérez, Jordi Rodón, Davendra Sohal, José M. Lizcano, Carles Domènech, José Alfón, Pere Gascón
Topics & Concepts
TolerabilityMedicinePharmacodynamicsPharmacokineticsDosingAutophagyAdverse effectClinical trialInternal medicinePharmacologyCancerOncologyApoptosisBiologyBiochemistryAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseCell death mechanisms and regulation