An antibody Fc engineered for conditional antibody-dependent cellular cytotoxicity at the low tumor microenvironment pH
Yutong Liu, Alison G. Lee, Annalee W. Nguyen, Jennifer A. Maynard
Abstract
ratios. This work shows the promise of mammalian cell display for Fc engineering and the feasibility of pH-selective Fc activation to provide a second dimension of selective tumor cell targeting.
Topics & Concepts
Antibody-dependent cell-mediated cytotoxicityChemistryAntibodyCytotoxicityFc receptorFragment crystallizable regionMolecular biologyMonoclonal antibodyAntigenReceptorIn vitroBiophysicsBiochemistryBiologyImmunologyMonoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins ResearchProtein purification and stability