The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19
Huabao Sun, Yiming Zhang, Li-Gui Huang, Qinan Lai, Qun Mo, Xin-Zhou Ye, Tao Wang, Zhongzhen Zhu, Xiaolin Lv, Yan-Ji Luo, Shi-Ding Gao, Jin-Song Xu, Haohao Zhu, Ting Li, Zhanke Wang
Abstract
To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.