A green bio-organic catalyst (taurine) promoted one-pot synthesis of (<i>R</i>/<i>S</i>)-2-thioxo-3,4-dihydropyrimidine(TDHPM)-5-carboxanilides: chiral investigations using circular dichroism and validation by computational approaches
Mehul P. Parmar, Disha P. Vala, Savan S. Bhalodiya, Dipti B. Upadhyay, Chirag D. Patel, Subham G. Patel, Srinivasa Rao Gandholi, Althaf hussain shaik, Amy Dunne Miller, Joaquina Nogales, Sourav Banerjee, José M. Padrón, Nasser Amri, Nagesh Kumar Kandukuri, Hitendra M. Patel
Abstract
Twenty-three new derivatives of ( R / S )-TDHPM-5-carboxanilide have been synthesized with up to 99% yield. All racemates were separated using chiral HPLC (Prep LC) which provided up to 99.99% purity. AC was determined using circular dichroism spectra.
Topics & Concepts
Circular dichroismYield (engineering)CatalysisChemistryHigh-performance liquid chromatographyCombinatorial chemistryNuclear chemistryStereochemistryChromatographyOrganic chemistryMaterials scienceMetallurgyMulticomponent Synthesis of HeterocyclesSynthesis and biological activityChemical Synthesis and Analysis