Cu-Catalyzed C–H Alkenylation of Benzoic Acid and Acrylic Acid Derivatives with Vinyl Boronates
Jianjun Li, Cheng-Gang Wang, Jin‐Feng Yu, Jin-Feng Yu, Peng Wang, Jin‐Quan Yu, Jin‐Quan Yu
Abstract
An efficient Cu-catalyzed C-H alkenylation with acyclic and cyclic vinyl boronates was realized for the first time under mild conditions. The scope of the vinyl borons and the compatibility with functional groups including heterocycles are superior than Pd-catalyzed C-H coupling with vinyl borons, providing a reliable access to multisubstituted alkenes and dienes. Subsequent hydrogenation of the product from the internal vinyl borons will lead to installation of secondary alkyls.
Topics & Concepts
ChemistryCatalysisAcrylic acidCompatibility (geochemistry)Organic chemistryBenzoic acidPolymer chemistryMedicinal chemistryCopolymerChemical engineeringPolymerEngineeringCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques