<scp>Metal‐Free</scp> Synthesis of <scp>2‐Aminobenzothiazoles</scp> via <scp>I<sub>2</sub>‐Catalyzed</scp> Tandem Cyclization Reaction of Amines and Carbon Disulfide
Ting Chen, Wei Feng, Ruitong Yang, Shanping Chen, Guo‐Jun Deng
Abstract
Comprehensive Summary A convenient approach for the construction of 2‐aminobenzothiazoles via I 2 ‐catalyzed tandem cyclization reaction of amines and carbon disulfide has been developed. The present approach starts from simple and readily available starting materials, affording a series of 2‐aminobenzothiazoles in up to 89% yields under metal‐free conditions. In this work, C—H/N—H functionalization was achieved and multiple C‐hetero bonds were successfully constructed in one pot.
Topics & Concepts
ChemistryTandemCatalysisCarbon disulfideDisulfide bondCombinatorial chemistryMetalOrganic chemistryBiochemistryComposite materialMaterials scienceSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsPhenothiazines and Benzothiazines Synthesis and Activities