Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy
Doo Sin Jo, So Jung Park, Ae‐Kyeong Kim, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Hyun Jun Park, Ji Hyun Shin, Jong Wook Chang, Peter K. Kim, Yong‐Keun Jung, Jae‐Young Koh, Seong‐Kyu Choe, Kyu‐Sun Lee, Dong‐Hyung Cho
Abstract
, and the HSPA9 mutants failed to rescue the loss of peroxisomes in Hsc70-5-depleted flies. Taken together, our findings suggest that the loss of HSPA9 enhances peroxisomal degradation by pexophagy.
Topics & Concepts
PeroxisomeBiologyCell biologyAutophagyGene knockdownBiochemistryGeneApoptosisAutophagy in Disease and TherapySignaling Pathways in DiseaseToxoplasma gondii Research Studies