Encapsulation of a Ru(η<sup>6</sup>-<i>p</i>-cymene) complex of the antibacterial drug trimethoprim into a polydiacetylene-phospholipid assembly to enhance its <i>in vitro</i> anticancer and antibacterial activities
Durairaj Gopalakrishnan, Chezhiyan Sumithaa, Madan Kumar Arumugam, Nattamai S. P. Bhuvanesh, Suvankar Ghorai, Priyadip Das, Mani Ganeshpandian
Abstract
The first report of a Ru(arene)–liposome nanoaggregate to enhance the <italic>in vitro</italic> anticancer activity of a Ru–arene complex in liver cancer cells.
Topics & Concepts
ChemistryPhospholipidAntibacterial activityEncapsulation (networking)Anticancer drugIn vitroTrimethoprimCombinatorial chemistryDrugAntibioticsPharmacologyBiochemistryBacteriaMembraneBiologyMedicineComputer scienceGeneticsComputer networkPolydiacetylene-based materials and applicationsNanoplatforms for cancer theranosticsAntimicrobial Peptides and Activities