Circulating Cell-Free Mitochondrial DNA in Pregnancy
Jessica L. Bradshaw, Spencer C. Cushen, Nicole Phillips, Styliani Goulopoulou
Abstract
Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the temporal changes of ccf-mtDNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications.
Topics & Concepts
Mitochondrial DNAPregnancyBiologyInflammationImmune systemMitochondrionCellInnate immune systemReceptorProgrammed cell deathDNACell biologyImmunologyCell-free fetal DNAApoptosisGeneticsFetusGenePrenatal diagnosisBirth, Development, and HealthReproductive System and PregnancyPregnancy and preeclampsia studies