Sequential Deletions of Interferon Inhibitors MGF110-9L and MGF505-7R Result in Sterile Immunity against the Eurasia Strain of Africa Swine Fever
Mingyang Ding, Wen Dang, Huanan Liu, Keshan Zhang, Fan Xu, Hong Tian, Huaguo Huang, Zhengwang Shi, Yongjie Sunkang, Xiaodong Qin, Yong Zhang, Haixue Zheng
Abstract
) provided sterile immunity and complete protection in a virulent challenge. Two doses were superior to 1 dose and provided additional protection. This study develops a new ASFV-specific live attenuated vaccine and may be a viable vaccine option against ASF.
Topics & Concepts
BiologyVirulenceInoculationAfrican swine fever virusVirologyTiterMutantImmunityAntibodyAttenuated vaccineInterferonStrain (injury)VirusIn vitroAfrican swine feverImmunologyImmune systemGeneGeneticsAnatomyAnimal Disease Management and EpidemiologyVector-Borne Animal DiseasesViral Infections and Immunology Research