Fabrication of hypoxia-responsive and uperconversion nanoparticles-modified RBC micro-vehicles for oxygen delivery and chemotherapy enhancement
Peiyuan Wang, Suhua Jiang, Yang Li, Qiang Luo, Jinyan Lin, Lidan Hu, Congjian Xu, Jun Zhu, Lingling Fan
Abstract
RBC based micro-vehicles were successfully fabricated for hypoxia activated O<sub>2</sub> precise delivery under 980 nm laser irradiation. Interestingly, owing to hypoxia alleviating, the chemotherapy enhancement of PTX for ovarian tumor was realized.
Topics & Concepts
Hypoxia (environmental)ChemotherapyNanoparticleOxygen deliveryFabricationOxygenChemistryIrradiationNanotechnologyMaterials scienceMedicineSurgeryPathologyPhysicsOrganic chemistryNuclear physicsAlternative medicineNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismHemoglobin structure and function