PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma
Branden A. Smeester, Nicholas J. Slipek, Emily J. Pomeroy, Kanut Laoharawee, Sara H. Osum, Alex T. Larsson, Kyle Williams, Natalie Stratton, Kenta Yamamoto, Joseph J. Peterson, Susan K. Rathe, Lauren J. Mills, Wendy A. Hudson, Margaret R. Crosby, Minjing Wang, Eric P. Rahrmann, Branden S. Moriarity, David A. Largaespada
Topics & Concepts
Autocrine signallingParacrine signallingCancer researchOsteosarcomaMAPK/ERK pathwayDU145Signal transductionCell growthCell biologyCell cultureChemistryBiologyReceptorMedicineInternal medicineCancerCancer cellGeneticsBiochemistryLNCaPCancer Cells and MetastasisSarcoma Diagnosis and TreatmentChemokine receptors and signaling