CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging
Jun Jin, Yunmei Mu, Huimin Zhang, Ines Sturmlechner, Chenyao Wang, Rohit R. Jadhav, Qiong Xia, Cornelia M. Weyand, Jörg J. Goronzy
Topics & Concepts
LysosomeInflammationCell biologyImmune systemCISHMitochondrial DNAGene silencingMitophagyBiologyChemistryImmunologyMessenger RNAAutophagyApoptosisBiochemistryGeneEnzymeIn situ hybridizationinterferon and immune responsesCytomegalovirus and herpesvirus researchInflammasome and immune disorders