SIRT3 mediates the effects of PCSK9 inhibitors on inflammation, autophagy, and oxidative stress in endothelial cells
Nunzia D’Onofrio, Francesco Prattichizzo, Raffaele Marfella, Celestino Sardu, Elisa Martino, Lucia Scisciola, Lorenza Marfella, Rosalba La Grotta, Chiara Frigé, Giuseppe Paolisso, Antonio Ceriello, Maria Luisa Balestrieri
Abstract
: Overall, these data suggest that PCSK9i bear intrinsic anti-inflammatory, anti-autophagic, and antioxidant properties in endothelial cells, and that these pleiotropic effects might be mediated, at least in part, by SIRT3. These results provide an additional mechanism supporting the emerging knowledge relative to the benefit of PCSK9i on CVD beyond LDL-lowering and uncover SIRT3 as a putative mediator of such pleiotropy.
Topics & Concepts
SIRT3Oxidative stressInflammationPCSK9InflammasomeAutophagyChemistryProprotein convertaseSirtuinCancer researchKEAP1Cell biologyMedicineApoptosisInternal medicineBiologyLDL receptorLipoproteinCholesterolBiochemistryTranscription factorGeneAcetylationLipoproteins and Cardiovascular HealthAtherosclerosis and Cardiovascular DiseasesMicrobial Metabolism and Applications