Long non-coding RNA MIR4435-2HG/microRNA-125a-5p axis is involved in myocardial ischemic injuries
Xiuling Wang, Lina Ren, Shuai Chen, Yanli Tao, Dandan Zhao, Chunwei Wu
Abstract
-treated AC16 cardiomyocytes. In addition, miR-125a-5p overexpression inhibited MTFP1 expression, and could stimulate the wild-type MTFP1 promoter luciferase activity but not the mutated one. Our findings revealed the role of MIR4435-2HG in MI-induced myocardium injury and cardiomyocytes apoptosis, disclosed a novel MIR4435-2HG/miR-125a-5p regulatory axis during myocardial I/R, and thus identified a potential target for the therapy of myocardial IR injury.
Topics & Concepts
ApoptosisGene knockdownOxidative stressMyocardial infarctionTUNEL assayTransfectionViability assayLuciferaseMolecular biologyMedicineBiologyInternal medicineGeneBiochemistryCancer-related molecular mechanisms research