1,4-Naphthoquinone thiazole urea hybrids bearing morpholine/piperazine: synthesis, crystal structure, aldose reductase and α-glycosidase enzyme inhibition, molecular docking, and electrochemical interaction with dsDNA
Çağla Efeoğlu, Selenay Sadak, Ertan Şahi̇n, Yeliz Demir, Cüneyt Türkeş, Bengi Uslu, Yahya Nural
Topics & Concepts
ChemistryMorpholineAldose reductaseStereochemistryCyclic voltammetryThiazoleElectrochemistryMoleculeDifferential pulse voltammetryMolecular modelMoietyDissociation constantPiperazineUreaDocking (animal)Trigonal bipyramidal molecular geometryCrystal structureEnzymeAldehyde ReductaseCombinatorial chemistryPyridiniumActive siteDNACrystallographyPyrazolePhthalimideHorseradish peroxidaseSingle crystalBinding constantDihydrofolate reductaseEthylenediamineBioactive Compounds and Antitumor AgentsCancer therapeutics and mechanismsCarbohydrate Chemistry and Synthesis