Endothelial cell CD36 deficiency prevents normal angiogenesis and vascular repair.
Lara Bou Khzam, Ni-Huiping Son, Adam E. Mullick, Nada A. Abumrad, Ira J. Goldberg
Abstract
CD36 affects angiogenesis, we studied 21-day recovery in post-hindlimb ischemia. EC-specific CD36 knockout mice had reduced blood flow recovery as assessed by laser Doppler imaging. EC content in post-ischemic muscle, assessed from CD31 expression, increased in ischemic muscle of control mice. However, mice with EC-specific CD36 deletion lacked the increase in CD31 and matrix metalloprotease 9 expression observed in controls. EC expression of CD36 and its function in FA uptake modulate angiogenic function and response to ischemia, likely due to reduced activation of the AMPK pathway.
Topics & Concepts
CD36AngiogenesisGene knockdownCD31Wound healingNeovascularizationChemistryCancer researchBiologyCell biologyMedicineImmunologyInternal medicineApoptosisBiochemistryReceptorPeroxisome Proliferator-Activated ReceptorsCancer, Lipids, and MetabolismCancer-related molecular mechanisms research