Suppressing ACQ of molecular photosensitizers by distorting the conjugated-plane for enhanced tumor photodynamic therapy
Han Sun, Lukun Li, Ruihua Guo, Zhe Wang, Yanhui Guo, Zhiliang Li, Fengling Song
Abstract
PDT for hypoxic tumors. This study demonstrates the power of sidechain chemistry in tuning the configuration and aggregation behaviors of porphyrins in water, offering a new path to boost the performance of PSs to fulfill the increasing clinical demands on cancer theranostics.
Topics & Concepts
Photodynamic therapyConjugated systemAqueous mediumPhotosensitizerNanotechnologyAqueous solutionChemistryMaterials sciencePhotochemistryOrganic chemistryPolymerNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPorphyrin and Phthalocyanine Chemistry