Shigella OspC3 suppresses murine cytosolic LPS sensing
Changhoon Oh, Ambika Verma, Mohib Hafeez, Brandon Hogland, Youssef Aachoui
Abstract
lacking OspC3 is attenuated in a caspase-11- and gasdermin D-dependent fashion. Overall, our study reveals that OspC3 suppresses cytosolic LPS detection in a broad array of mammals.
Topics & Concepts
Shigella flexneriPyroptosisEffectorInflammasomeCytosolShigellaLipopolysaccharideMicrobiologyCell biologyBiologyType three secretion systemSecretionCaspase 1ChemistryBiochemistryInflammationImmunologyEscherichia coliGeneVirulenceEnzymeInflammasome and immune disordersImmune Response and InflammationStreptococcal Infections and Treatments