Ferroptosis contributes to methylmercury-induced cytotoxicity in rat primary astrocytes and Buffalo rat liver cells
Lihua Dong, Bobo Yang, Yu Zhang, Suhua Wang, Fang Li, Guangwei Xing, Marcelo Farina, Yubin Zhang, Kwaku Appiah‐Kubi, Alexey A. Tinkov, Michael Aschner, Haifeng Shi, Tingting Liu, Rongzhu Lu
Topics & Concepts
GPX4CytotoxicityLipid peroxidationChemistryGlutathioneViability assayProgrammed cell deathReactive oxygen speciesIntracellularCytosolBiochemistryOxidative stressDeferoxamineFerritinGlutathione peroxidaseApoptosisMolecular biologyBiologyIn vitroEnzymeFerroptosis and cancer prognosisArsenic contamination and mitigationMercury impact and mitigation studies