Identification of novel CD44v6-binding peptides that block CD44v6 and deliver a pro-apoptotic peptide to tumors to inhibit tumor growth and metastasis in mice
Fatima Khan, Smriti Gurung, Gowri Rangaswamy Gunassekaran, Sri Murugan Poongkavithai Vadevoo, Lianhua Chi, Uttapol Permpoon, Md. Enamul Haque, Yun-Ki Lee, Soo-woong Lee, Soyoun Kim, Byung-Heon Lee
Abstract
These results suggest that NLN and NEW are promising metastasis-inhibiting peptide therapeutics and targeting moieties for CD44v6-expressing metastases.
Topics & Concepts
InternalizationCancer researchMetastasisCD44PeptideCrizotinibCancer cellMolecular biologyChemistryBiologyCellCancerMedicineBiochemistryPathologyLung cancerGeneticsMalignant pleural effusionLiver physiology and pathologyProteoglycans and glycosaminoglycans researchGlycosylation and Glycoproteins Research