Design, synthesis and antitumor activity of novel thiophene- triazine derivatives bearing arylurea unit as potent PI3K/mTOR inhibitorss
Shan Xu, Leixuan Luo, Xin Sun, Yang Yang, Qiuyan Guo, Zhiyan Jiang, Yingliang Wu
Topics & Concepts
HeLaPI3K/AKT/mTOR pathwayChemistryKinaseCell cultureCytotoxicityIC50Cancer cellPharmacologyCancerStereochemistryCellBiochemistryIn vitroSignal transductionBiologyGeneticsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activityCancer Mechanisms and Therapy