Study of the immunoregulatory effect of Lactobacillus rhamnosus 1.0320 in immunosuppressed mice
Da Gao, Zhijing Liu, Fei Liu, Lijun Chen, Wan Wang, Jiage Ma, Cong Xu, Zhanmei Jiang, Juncai Hou
Abstract
Lactobacillus can effectively enhance the immune function of the body. The aim of this study was to evaluate the immunomodulatory effect of Lactobacillus rhamnosus 1.0320 on cyclophosphamide (CTX)-induced immunosuppressive mice. The results showed that CTX can successfully induce immunosuppression in mice. Compared with the CTX-induced immunosuppressed mice, Lactobacillus rhamnosus 1.0320 alleviated the body weight loss of mice and increased the spleen index and the thymus index. Lactobacillus rhamnosus 1.0320 significantly increased splenic lymphocyte proliferation, phagocytosis of neutral red by macrophages, NK cell activity, the carbon particle clearance index, delayed type hypersensitivity (DTH) and serum half-hemolysis concentration (HC50) in immunosuppressed mice. In addition, Lactobacillus rhamnosus 1.0320 could upregulate the serum levels of IL-6, IL-10, IL-12, TNF-α and IgG, restore the damage to the small intestine and liver tissue in immunosuppressed mice. Taken together, Lactobacillus rhamnosus 1.0320 can significantly enhance the immune function of immunosuppressed mice.