Crizotinib Shows Antibacterial Activity against Gram-Positive Bacteria by Reducing ATP Production and Targeting the CTP Synthase PyrG
Yun-Dan Zheng, Tairan Zhong, Haiming Wu, Nan Li, Zuye Fang, Linlin Cao, Xingfeng Yin, Qing‐Yu He, Ruiguang Ge, Xuesong Sun
Abstract
via suppressing ATP production and pyrimidine metabolism. Crizotinib was found to disturb pyrimidine metabolism by targeting the CTP synthase PyrG, thus reducing DNA synthesis. This unique mechanism of action may explain the decreased development of resistance by Staphylococcus aureus to crizotinib. This study provides a potential option for the treatment of drug-resistant bacterial infections in the future.
Topics & Concepts
CrizotinibATP synthaseBacteriaGramBiologyPharmacologyGeneticsMicrobiologyChemistryMedicineEnzymeBiochemistryInternal medicineMalignant pleural effusionPleural effusionBiochemical and Molecular ResearchTuberculosis Research and EpidemiologyPneumocystis jirovecii pneumonia detection and treatment