Bronchial epithelial SIRT1 deficiency exacerbates cigarette smoke induced emphysema in mice through the FOXO3/PINK1 pathway
Hui Jiang, Yaona Jiang, Yuanri Xu, Dong Yuan, Yaqing Li
Abstract
: These results demonstrated that the detrimental effects of SIRT1 deficiency on cell senescence associated with insufficient mitophagy, and involved the FOXO3/PINK1 signaling pathway.
Topics & Concepts
MitophagyFOXO3PINK1SirtuinSirtuin 1SenescenceMitochondrionCell biologyBiologyOxidative stressApoptosisParkinAutophagyImmunologyAcetylationSignal transductionDownregulation and upregulationMedicineEndocrinologyInternal medicineBiochemistryProtein kinase BGeneParkinson's diseaseDiseaseSirtuins and Resveratrol in MedicineAutophagy in Disease and TherapyChronic Obstructive Pulmonary Disease (COPD) Research