Highly enantioselective copper-catalyzed propargylic amination to access <i>N</i>-tethered 1,6-enynes
Sijia Li, Jian Huang, Jin-Yu He, Rui-Jin Zhang, Hao-Dong Qian, Xue-Lin Dai, Han‐Han Kong, Hao Xu
Abstract
-tethered 1,6-enynes were synthesized in good to excellent yields with excellent enantioselectivities. Utilization of transition metal-catalyzed cycloisomerization of 1,6-enynes provides several enantioselectively enriched chiral five-membered N-heterocycles efficiently.
Topics & Concepts
CycloisomerizationAminationEnantioselective synthesisAllylic rearrangementCatalysisChemistryCopperCombinatorial chemistryLigand (biochemistry)Transition metalOrganic chemistryReceptorBiochemistryCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms