Design, synthesis, and biological evaluation of N-(pyridin-3-yl)pyrimidin-4-amine analogues as novel cyclin-dependent kinase 2 inhibitors for cancer therapy
Wenbin Zeng, Tangyang Ji, Yanting Zhang, Yufeng Ma, Rou Li, Wen‐Wei You, Pei‐Liang Zhao
Topics & Concepts
HeLaChemistryCyclin-dependent kinase 2IC50Cancer cellKinaseCell cyclePalbociclibApoptosisCancer researchCancerBiochemistryPharmacologyCellIn vitroBiologyGeneticsMetastatic breast cancerBreast cancerAdvanced Breast Cancer TherapiesCancer-related Molecular PathwaysCancer therapeutics and mechanisms