Individuals with common diseases but with a low polygenic risk score could be prioritized for rare variant screening
Tianyuan Lu, Sirui Zhou, Haoyu Wu, Vincenzo Forgetta, Celia M.T. Greenwood, J. Brent Richards
Topics & Concepts
Polygenic risk scoreMedicineInternal medicineGeneticsBiologySingle-nucleotide polymorphismGenotypeGeneGenomics and Rare DiseasesGenetic Associations and EpidemiologyBRCA gene mutations in cancer