Nickel-Catalyzed Three-Component Reductive Alkylacylation of Electron-Deficient Activated Alkenes
Lin Wang, Chuan Wang
Abstract
Herein, we present a nickel-catalyzed three-component reductive alkylacylation of electron-deficient activated alkenes with tertiary alkyl bromides and acid anhydrides. This method enables the efficient preparation of a variety of ketones with broad substrate scope and high functionality tolerance starting from simple precursors. On the basis of the preliminary mechanistic investigations, a catalytic cycle involving the synergistic interaction of nickel, zinc, and MgCl2 is proposed as the major reaction pathway.
Topics & Concepts
ChemistryCatalysisNickelCatalytic cycleCombinatorial chemistryAlkylSubstrate (aquarium)Reductive eliminationZincComponent (thermodynamics)Organic chemistryPhysicsOceanographyGeologyThermodynamicsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsChemical Synthesis and Analysis