Identification of highly selective covalent inhibitors by phage display
Shiyu Chen, S. Lovell, Sumin Lee, Matthias Fellner, Peter D. Mace, Matthew Bogyo
Topics & Concepts
Covalent bondCysteineChemistryLinkerSmall moleculeElectrophileCombinatorial chemistryPhage displayProteasesChemical biologyBiochemistryStereochemistryEnzymePeptideOrganic chemistryCatalysisComputer scienceOperating systemMonoclonal and Polyclonal Antibodies ResearchClick Chemistry and ApplicationsChemical Synthesis and Analysis