Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome
Taru Garthwaite, Tanja Sjöros, Saara Laine, Mikko Koivumäki, Henri Vähä‐Ypyä, Olli Eskola, Johan Rajander, Petri Kallio, Maria Saarenhovi, Eliisa Löyttyniemi, Harri Sievänen, Noora Houttu, Kirsi Laitinen, Kari K. Kalliokoski, Tommi Vasankari, Juhani Knuuti, Ilkka Heinonen
Abstract
Objective The objective of the study was to investigate the associations of sedentary time, physical activity, and cardiorespiratory fitness with skeletal muscle glucose uptake (GU). Methods Sedentary time and physical activity were measured with accelerometers and VO 2 max with cycle ergometry in 44 sedentary adults with metabolic syndrome. Thigh muscle GU was determined with [ 18 F]FDG‐PET imaging. Results Sedentary time ( β = −0.374), standing ( β = 0.376), steps ( β = 0.351), and VO 2 max ( β = 0.598) were associated with muscle GU when adjusted for sex, age, and accelerometer wear time. Adjustment for body fat‐% turned all associations non‐significant. Conclusion Body composition is a more important determinant of muscle GU in this population than sedentary time, physical activity, or fitness.