Spatially precise chemo-radio-immunotherapy by antibody drug conjugate directed tumor radiosensitization to potentiate immunotherapies
Mahsa Mortaja, Stephen Adams, Rana R. McKay, Zhiyong Wang, Sunil J. Advani
Abstract
Concurrent chemo-radiotherapy is standard of care for locally advanced cancer patients. While radiotherapy and immuno-oncology have advanced precision oncology, chemotherapies in the chemo-radiotherapy paradigm remain non-targeted cytotoxins. Antibody drug conjugates offer an opportunity for targeted radiosensitization that stimulates immune responses while protecting normal tissues. Here, we discuss the rationale for combining antibody drug conjugates, radiotherapy and immunotherapies and opportunities for clinical translation to advance towards targeted chemo-radio-immunotherapy precision cancer care.
Topics & Concepts
ImmunotherapyMedicineRadiation therapyAntibody-drug conjugateOncologyDrugCancer researchAntibodyCancerInternal medicineMonoclonal antibodyImmunologyPharmacologyCancer Immunotherapy and BiomarkersNeuroblastoma Research and TreatmentsCAR-T cell therapy research