Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors
Jun Gao, Xuegui Liu, Bing Zhang, Qing Mao, Zhuo Zhang, Qian Zou, Xiwen Dai, Shaojie Wang
Topics & Concepts
ChemistryMoietyXanthine oxidaseAllopurinolStereochemistryIndole testOxadiazoleHyperuricemiaHydrogen bondXanthine oxidase inhibitorProton NMRCombinatorial chemistryEnzymeUric acidBiochemistryMoleculeOrganic chemistryPathologyMedicineGout, Hyperuricemia, Uric AcidEosinophilic Disorders and SyndromesCase Reports on Hematomas