Fluorescent 7-azaindole<i>N</i>-linked 1,2,3-triazole: synthesis and study of antimicrobial, molecular docking, ADME and DFT properties
Kanika Sharma, Ram Kumar Tittal, Kashmiri Lal, Ramling S. Mathpati, Vikas D. Ghule
Abstract
Two libraries of antimicrobial and fluorescent 7-azaindole N -linked benzyl/phenyl 1,2,3-triazole hybrids have been synthesized via Cu (II) catalyzed click reaction. Molecular docking, ADME, Molinspiration and DFT studies were also carried out.
Topics & Concepts
ChemistryADMEAntimicrobialCombinatorial chemistry1,2,3-TriazoleDocking (animal)TriazoleClick chemistryPharmacophoreStereochemistryFluorescenceComputational chemistryOrganic chemistryBiochemistryIn vitroPhysicsMedicineNursingQuantum mechanicsClick Chemistry and ApplicationsSynthesis and Biological EvaluationSynthesis and biological activity