A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment
Miao Zhang, Peng Xu, Yuan Ding, Xiang Ke, Kai Ren, Qiangwei Xin, Meng Qin, Jing Xie, Jianshu Li
Abstract
experiments confirmed the triple function of the CB on superlubrication, sequence controlled release and anti-inflammatory effects demonstrated by Micro CT, histological analysis and qRT-PCR. Overall, the CB is a promising long-acting lubricating therapeutic agent, with potential for OA treatment or other diseases.
Topics & Concepts
NanocarriersBrushDrug deliveryLubricationDrugPolymerMaterials scienceDual (grammatical number)Polymer brushNanotechnologyChemistryPharmacologyMedicineComposite materialPolymerizationArtLiteraturePolymer Surface Interaction StudiesDendrimers and Hyperbranched PolymersNanoparticle-Based Drug Delivery