Melatonin protects against chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1
Ying Guo, Junyan Sun, Shixia Bu, Boning Li, Qiuwan Zhang, Qian Wang, Dongmei Lai
Abstract
by regulating autophagy and SIRT1, which could be abolished by SIRT1 inhibitor, Ex527 and autophagy inhibitor Bafilomycin A1 (Baf A1). These data indicate that melatonin can mitigate chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1 and autophagy, providing new understanding for stress-related meiotic errors in MII oocytes and suggesting melatonin and SIRT1 could be new targets for optimizing culture system of oocytes as well as fertility management.
Topics & Concepts
MelatoninAutophagyBiologyOocyteOxidative stressMeiosisCell biologyChronic stressSirtuin 1EndocrinologyInternal medicineGeneticsMedicineApoptosisDownregulation and upregulationGeneEmbryoGenetics, Aging, and Longevity in Model OrganismsCircadian rhythm and melatoninReproductive Biology and Fertility