Sesquiterpenoids from <i>Chrysanthemum indicum</i> with Inhibitory Effects on NO Production
Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang
Abstract
Three new guaianolide lactones (1–3) and four new 9-oxonerolidol glucosides (5–8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1–4 and 15 and flavones 17 and 18 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values in the range 0.2–27.0 μM.
Topics & Concepts
FlavonesCircular dichroismSesquiterpeneStereochemistryChemistryHydrolysisInhibitory postsynaptic potentialAsteraceaeNitric oxideIC50In vitroBotanyBiologyOrganic chemistryBiochemistryChromatographyNeurosciencePhytochemistry and Biological ActivitiesSesquiterpenes and Asteraceae StudiesNatural product bioactivities and synthesis