Iridium-catalyzed enantioselective addition of an <i>N</i>-methyl C–H bond to α-trifluoromethylstyrenes <i>via</i> C–H activation
Daisuke Yamauchi, Ikumi Nakamura, Takahiro Nishimura
Abstract
C-H activation to give chiral γ-branched amine derivatives having a trifluoromethyl-substituted stereocenter. It was found that a bulky and electron-withdrawing group at the 3-position of 2-(methylamino)pyridines was necessary for the present C-H addition reaction catalyzed by a cationic iridium/chiral bisphosphine complex.
Topics & Concepts
IridiumEnantioselective synthesisChemistryCationic polymerizationStereocenterCatalysisPyridineTrifluoromethylMedicinal chemistryAmine gas treatingStereochemistryOrganic chemistryAlkylFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms